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Ubiquinol 100 Mg 60 Gels
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Best Ubiquinol (90 softgels - 50 mg) by Doctor's Best
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Item #: 462202014
Price: 20.99
Retail price: 49.99
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Best Ubiquinol featuring Kaneka QH contains the reduced form of coenzyme Q10. Both ubiquinol (CoQ10-H2) and ubiquinone (CoQ10) are metabolically active, and are found naturally in the body and in food sources. The two forms are interchangeable as the body appears to keep the reduced and oxidized forms in the "total pool" at a constant ratio.1,2,3 Each form has unique roles to play in cells including antioxidant actions and enhancement of energy production in the mitochondria. The commonly available supplement form of coenzyme Q10 has been the oxidized form (ubiquinone), as until recently the reduced form was difficult to manufacture due to its rapid oxidation in the air. New technology has allowed for the manufacturing of stable coenzyme Q10 in the reduced form.4 The results from an animal study that compared the absorption of the two different forms, as well as a human study showing significant absorption of ubiquinol, together suggest that taking ubiquinol orally may offer improved bioavailability in individuals who have difficulty achieving high levels of this nutrient, such as aging adults or those concerned with nutrient absorption.4 Comparison studies of the two forms are now necessary in humans to confirm this idea, as well as determine the specific circumstances under which ubiquinol may be more beneficial.
BenefitsUbiquinol has powerful antioxidant actions in target cells
Although ubiquinone (oxidized coenzyme Q10) and ubiquinol (reduced coenzyme Q10) are kept at a constant ratio within the body, the majority of the total coenzyme Q10 pool is made up of ubiquinol. In fact, when ubiquinone is taken orally, much of it appears to be rapidly converted into ubiquinol. 1,4 Ubiquinol functions as a potent antioxidant in humans, including in low-density lipoproteins (LDLs) where it protects them from oxidative damage.1,4,5 The coenzyme Q10 molecule can be found in all membranes throughout cells.6 It appears to works in conjunction with both vitamin E and vitamin C to provide antioxidant actions throughout the body.7
Coenzyme Q10 supports mitochondria to enhance cellular energy production
Coenzyme Q10, with its widespread distribution throughout the body, plays a crucial role in mitochondrial physiology as a critical member of the electron transport chain. This transport chain, which is part of cellular respiration, leads to the formation of adenosine triphosphate (ATP), our body's primary energy source. Levels of this key nutrient may decline as a healthy person ages.7,8 Animal studies have found that supplementation can restore normal levels in certain tissues 6, and human studies suggest that supplementing with this enzyme may have increased benefits when a person has depleted levels. 7
Coenzyme Q10 supports healthy heart functioning
Concentrations of coenzyme Q10 are understandably high in the heart as these muscle cells require high levels of energy to constantly function optimally. A number of studies (both animal and human) strongly suggest that coenzyme Q10 supplementation is supportive for healthy heart functioning and for maintaining cardiovascular system health.7,9
Ubiquinol has been studied for safety and bioavailability in humans
A recently published single-blind placebo-controlled study in healthy subjects found no safety concerns in people who took Kaneka’s QH ubiquinol supplement orally at doses of up to 300 milligrams daily for up to four weeks.4 Single oral doses of either 150 milligrams or 300 milligrams were given to fifteen healthy men and women, and standard laboratory testing (including hematology, blood chemistry, and urinalysis) as well as physical examination and electrocariography (EKG) results showed no clinically significant changes when tested two days after supplementation as compared to before the taking the supplement. In addition to the single dose study, 80 healthy volunteers were given either placebo, 90, 150 or 300 milligrams of ubiquinol each day for four weeks, and again no clinically significant differences were seen in any of the testing parameters after two and four weeks of supplementation, nor were there differences two weeks after discontinuation of the supplement. By monitoring levels in the blood, the authors found that ubiquinol was well absorbed.4
Studies in several animals also reveal no concern of toxicity in doses of ubiquinol up to 200 milligrams per kilogram of body weight for up to thirteen weeks.4 When compared to humans, this dose level is enormously higher than the recommended doses. Supplementation with ubiquinol appeared to be safe at even higher levels (up to 600 milligrams per kilogram body weight) in a study using a different animal. In vitro assays additionally found no safety concerns for the use of ubiquinol, as it was found to be non-mutagenic and did not cause damage to chromosomes in cells.
Scientific References
1. Mohr, D., V.W. Bowry, and R. Stocker, Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation. Biochim Biophys Acta, 1992. 1126(3): p. 247-54.
2. Weber, C., et al., Effect of dietary coenzyme Q10 as an antioxidant in human plasma. Mol Aspects Med, 1994. 15 Suppl: p. s97-102.
3. Okamoto, T., et al., Human serum ubiquinol-10 levels and relationship to serum lipids. Int J Vitam Nutr Res, 1989. 59(3): p. 288-92.
4. Hosoe, K., et al., Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol, 2007. 47(1): p. 19-28.
5. Stocker, R., V.W. Bowry, and B. Frei, Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proc Natl Acad Sci U S A, 1991. 88(5): p. 1646-50.
6. Crane, F.L., Biochemical functions of Coenzyme Q10. Journal of the American College of Nutrition, 2001. 20(6): p. 591-598.
7. Jones, K., et al., Coenzyme Q-10 and cardiovascular health. Alternative therapies, 2004. 10(1): p. 22-31.
8. Schulz, C., et al., Comparison of the relative bioavailability of different coenzyme Q10 formulations with a novel solubilizate (Solu Q10). Int J Food Sci Nutr, 2006. 57(7-8): p. 546-55.
9. Coenzyme Q10. Monograph. Altern Med Rev, 2007. 12(2): p. 159-68. |
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Ubiquinol 50mg, 60 Softgels, Olympian Labs
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Item #: 458559979
Price: 29.96
Retail price: 38.87
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| Olympian Labs Ubiquinol Dietary Supplement. Olympian Labs guarantees that all Olympian Labs products are of the highest quality. Amount Per Serving: Ubiquinol 50 mg (Kaneka QH™ active form of Coenzyme Q10). |
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Best Ubiquinol featuring Kaneka's QH, 90 Softgels, from Doctor's Best
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Item #: 457844849
Price: 19.95
Retail price: 49.99
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| Best Ubiquinol featuring Kaneka QH contains the reduced form of coenzyme Q10. Both ubiquinol (CoQ10-H2) and ubiquinone (CoQ10) are metabolically active, and are found naturally in the body and in food sources. The two forms are interchangeable as the body appears to keep the reduced and oxidized forms in the "total pool" at a constant ratio. Each form has unique roles to play in cells including antioxidant actions and enhancement of energy production in the mitochondria. Ubiquinol Benefits: Ubiquinol has powerful antioxidant actions in target cells. Coenzyme Q10 supports mitochondria to enhance cellular energy production. Coenzyme Q10 supports healthy heart functioning. Ubiquinol has been studied for safety and bioavailability in humans. |
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Ubiquinol 50mg, 30 Softgels, Olympian Labs
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Item #: 458559978
Price: 15.26
Retail price: 19.95
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| Olympian Labs Ubiquinol Dietary Supplement. Olympian Labs guarantees that all Olympian Labs products are of the highest quality. Amount Per Serving: Ubiquinol 50 mg (Kaneka QH™ active form of Coenzyme Q10). |
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Super Ubiquinol CoQ10 (60 softgels - 100 mg) by Life Extension
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Item #: 462569669
Price: 39.99
Retail price: 62.00
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The mitochondria are the cells' energy powerhouses, and coenzyme Q10 (CoQ10) is an essential component of healthy mitochondrial function.
CoQ10 is required to convert fats and sugars into cellular energy, yet the natural production of CoQ10 declines precipitously with advancing age. When the body has an ample amount of CoQ10 the mitochondria can work most efficiently throughout the entire body including the most densely populated area, the heart. CoQ10 is also a potent antioxidant, helping protect the proteins, lipids and DNA of mitochondria from oxidation, and supporting mitochondrial function.
More humans are supplementing with coenzyme Q10 than ever before. One reason is the increased awareness that the "statin" drugs used to lower LDL and cholesterol deplete the body of CoQ10. What most doctors don't know, however, is that normal aging may result in more of a reduction in CoQ10 than taking statin drugs. For example, while statin drugs have been shown to reduce plasma CoQ10 by 40%,6 the aging process reduces CoQ10 levels in the heart muscle wall by 72%. What is particularly frightening is the thought of people taking statin drugs who fail to supplement with CoQ10. The CoQ10 deficit caused by the dual affects of aging and statin drug use could result in severe depletion of cellular vitality.
When coenzyme Q10 is orally ingested, only a certain percentage is actually absorbed into the bloodstream. Findings in human subjects indicate that higher doses of CoQ10 provide significantly better effects than the doses that supplement users typically take. Since CoQ10 is such an expensive nutrient, an alternative to taking higher doses is to increase the amount of CoQ10 that is absorbed. Life Extension offers the highly bioavailable ubiquinol form of CoQ10 in a patented delivery system that offers superior absorption level.
When it comes to choosing a CoQ10 supplement, the primary factor is how many swallowed milligrams actually make it into your bloodstream. Coenzyme Q10 is a notoriously difficult nutrient to absorb. A recent study showed that in seriously ill patients, conventional ubiquinone CoQ10 was hardly detectable in the blood, whereas the new ubiquinol resulted in significant blood level increases and subsequent clinical improvements.
Scientific studies show that ubiquinol remains in the blood far longer than ubiquinone. In studies measuring exercise-induced fatigue, ubiquinol was 90% more effective than ubiquinone. In middle-aged mice, ubiquinol was shown to be 40% more effective in slowing measurements of aging compared to ubiquinone.Japanese researchers have developed a novel ubiquinol delivery system that has been shown to double-peak CoQ10 blood levels (i.e., 100% greater peak absorption) in mice compared to the original ubiquinol formula. This enhanced ubiquinol formula also achieved a 66% greater amount of CoQ10 in blood over 24 hours compared to the original formula. Life Extension is the first supplement company to distribute this enhanced-absorbing ubiquinol. |
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Super Ubiquinol CoQ10 (30 softgels - 50 mg) by Life Extension
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Item #: 458463746
Price: 13.09
Retail price: 20.99
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The mitochondria are the cells' energy powerhouses, and coenzyme Q10 (CoQ10) is an essential component of healthy mitochondrial function.
CoQ10 is required to convert fats and sugars into cellular energy, yet the natural production of CoQ10 declines precipitously with advancing age. When the body has an ample amount of CoQ10 the mitochondria can work most efficiently throughout the entire body including the most densely populated area, the heart. CoQ10 is also a potent antioxidant, helping protect the proteins, lipids and DNA of mitochondria from oxidation, and supporting mitochondrial function.
More humans are supplementing with coenzyme Q10 than ever before. One reason is the increased awareness that the "statin" drugs used to lower LDL and cholesterol deplete the body of CoQ10. What most doctors don't know, however, is that normal aging may result in more of a reduction in CoQ10 than taking statin drugs. For example, while statin drugs have been shown to reduce plasma CoQ10 by 40%,6 the aging process reduces CoQ10 levels in the heart muscle wall by 72%. What is particularly frightening is the thought of people taking statin drugs who fail to supplement with CoQ10. The CoQ10 deficit caused by the dual affects of aging and statin drug use could result in severe depletion of cellular vitality.
When coenzyme Q10 is orally ingested, only a certain percentage is actually absorbed into the bloodstream. Findings in human subjects indicate that higher doses of CoQ10 provide significantly better effects than the doses that supplement users typically take. Since CoQ10 is such an expensive nutrient, an alternative to taking higher doses is to increase the amount of CoQ10 that is absorbed. Life Extension offers the highly bioavailable ubiquinol form of CoQ10 in a patented delivery system that offers superior absorption level.
When it comes to choosing a CoQ10 supplement, the primary factor is how many swallowed milligrams actually make it into your bloodstream. Coenzyme Q10 is a notoriously difficult nutrient to absorb. A recent study showed that in seriously ill patients, conventional ubiquinone CoQ10 was hardly detectable in the blood, whereas the new ubiquinol resulted in significant blood level increases and subsequent clinical improvements.
Scientific studies show that ubiquinol remains in the blood far longer than ubiquinone. In studies measuring exercise-induced fatigue, ubiquinol was 90% more effective than ubiquinone. In middle-aged mice, ubiquinol was shown to be 40% more effective in slowing measurements of aging compared to ubiquinone.Japanese researchers have developed a novel ubiquinol delivery system that has been shown to double-peak CoQ10 blood levels (i.e., 100% greater peak absorption) in mice compared to the original ubiquinol formula. This enhanced ubiquinol formula also achieved a 66% greater amount of CoQ10 in blood over 24 hours compared to the original formula. Life Extension is the first supplement company to distribute this enhanced-absorbing ubiquinol. |
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QH-Absorb 200 mg, Ubiquinol Kaneka QH, 30 Softgels, Jarrow Formulas
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Item #: 461488443
Price: 37.00
Retail price: 49.95
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| Jarrow QH-Absorb Reduced Form Co-Q10 (Ubiquinol) The most bioavailable and active antioxidant form of Co-Q10. High absorption natural proliposome delivery system. Ubiquinol is the reduced (active antioxidant) form of Co-Q10, the form which is directly used in human metabolism as a lipid-soluble antioxidant. While standard Co-Q10 (ubiquinone) supplements can be activated in the body, this activation can be less efficient in some individuals, based on age or genetics. Ubiquinol also has superior bioavailability to ubiquinone, as demonstrated in clinical trials. |
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QH-Absorb 30mg, Ubiquinol Kaneka QH, 60 Softgels, Jarrow Formulas
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Item #: 458611842
Price: 16.28
Retail price: 21.95
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| Jarrow QH-absorb™ The most bioavailable and active antioxidant form of Co-Q10. High absorption natural proliposome delivery system. Ubiquinol is the reduced (active antioxidant) form of Co-Q10, the form which is directly used in human metabolism as a lipid-soluble antioxidant. While standard Co-Q10 (ubiquinone) supplements can be activated in the body, this activation can be less efficient in some individuals, based on age or genetics. |
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QH-Absorb 100mg, Ubiquinol Kaneka QH, 60 Softgels, Jarrow Formulas
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Item #: 458611841
Price: 41.44
Retail price: 55.95
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| Jarrow QH-absorb™ The most bioavailable and active form of Co-Q10. High absorption natural proliposome delivery system. Ubiquinol is the reduced (active antioxidant) form of Co-Q10, the form which is directly used in human metabolism as a lipid-soluble antioxidant. While standard Co-Q10 (ubiquinone) supplements can be activated in the body, this activation can be less efficient in some individuals, based on age or genetics. |
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Ubiquinol CoQH 100mg, CoQ10 with Heightened Absorption, 30 Softgels, Source Naturals
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Item #: 458915438
Price: 14.78
Retail price: 28.98
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| Source Naturals Ubiquinol CoQH Active Form of CoQ10. For Heart Brain and Immunity. CoQ10 with Heightened Absorption. Source Naturals Ubiquinol CoQH is a newly available form of the powerful antioxidant CoQ10. This superior form offers you the same broad-ranging benefits, but with heightened absorption which yields higher concentrations of CoQ10 in the blood. |
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